昆虫抗菌肽在植物病害防治的研究进展

Advances in Insect Antimicrobial Peptides: Mechanisms and Applications in Plant Disease Management

  • 摘要: 为应对传统农药耐药性危机及植物病害防治需求,综述梳理了昆虫抗菌肽(AMPs)在植物病害防治中的研究进展。依据其二级结构特征,AMPs可分为α-螺旋多肽、β-折叠多肽、αβ混合型多肽和无规则卷曲多肽4大类,其通过膜靶向(桶板、地毯、环形孔等)和非膜靶向(作用于核酸、蛋白质等)机制发挥抗菌作用。多种AMPs在番茄青枯病、水稻白叶枯病等植物病害防治中效果显著,可通过转基因、外部施用、体内递送等方式应用。然而,其也存在易降解、成本高及潜在抗性等问题,未来需从分子设计、工艺开发和生态监测等方面深入研究,以推动其在植物病害防控中的规模化应用。

     

    Abstract: In response to the crisis of resistance to conventional pesticides and the demand for plant disease management, this paper reviews summarizes recent research progress on insect antimicrobial peptides(AMPs)and their application in controlling plant diseases. Structurally, AMPs can be categorized into four major classes: α-helical peptides, β-sheet peptides, αβ mixed-type peptides and unstructured random coils. They exert antimicrobial effects through membrane-targeting mechanisms(including barrel-stave, carpet, toroidal pore and so on)and non-membrane-targeting mechanisms(such as interactions with nucleic acids and proteins). Studies have demonstrated the efficacy of various AMPs in controlling plant diseases, including bacterial wilt of tomato and bacterial leaf blight of rice. These AMPs can be applied via transgenic expression or spray formulations. However, challenges such as susceptibility to degradation, high production costs, and potential resistance development remain. Future research should focus on molecular design, process optimization, and ecological monitoring to facilitate their large-scale application in plant disease management.

     

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